Wipe sampling locations should be based on identifying drug preparation, administration and disposal areas with potential for trace contamination. USP <800> recommends, at a minimum, the following locations:
– Interior of the containment primary engineering control (C-PEC) (eg, biological safety cabinet or containment ventilated enclosure)
– Pass-through chambers
– Surfaces in staging or work areas near the C-PEC
– Areas adjacent to C-PECs (eg, floors directly under the C-PEC, staging and dispensing spaces)
– Areas immediately outside the HD buffer room or the containment segregated compounding area (C-SCA)